288 datasets found
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Federal
Single cell transcriptional profiling of spleens from mice flown on Rodent Research Reference Mission-2 (RRRM-2)
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Characterizing Epigenetic Changes in Methylation Mutants (elp2-5 and met1-7) in Response to Spaceflight. [RNA-Seq]
National Aeronautics and Space Administration —
Epigenetic changes in the DNA methylome are increasingly shown to play an integral role in regulating gene expression necessary for plants adaption to environmental... -
Federal
Transcriptional profiling of spleens from mice flown on the RR-9 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-9 (RR-9) mission was to use mice to understand the molecular basis of phenomena that affect astronauts during long-duration... -
Federal
Drosophila melanogaster gene expression changes after spaceflight.
National Aeronautics and Space Administration —
Gene expression levels were determined in 3rd instar and adult Drosophila melanogaster reared during spaceflight, to elucidate the genetic and molecular mechanisms... -
Federal
Single cell transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from mice flown on Rodent Research Reference Mission-2 (RRRM-2)
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
National Aeronautics and Space Administration —
Given the limited knowledge of the biological impact of spaceflight, a multi-omics, systems biology approach was used to investigate NASA’s GeneLab data and astronaut... -
Federal
Proton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
National Aeronautics and Space Administration —
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological... -
Federal
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight [plasma proteomics]
National Aeronautics and Space Administration —
Among the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass. One signaling pathway that plays an important role in... -
Federal
Draft Genome sequences of Rhodotorula mucilaginosa isolated from the International space station
National Aeronautics and Space Administration —
Draft Genome sequences of Rhodotorula mucilaginosa isolated from the International space station. -
Federal
CI Asteroid Regolith as an In Situ Plant Growth Medium for Space Crop Production
National Aeronautics and Space Administration —
Human expansion into the solar system is currently at the forefront of space research. For our astronauts to survive, they will need to be fed a healthy and... -
Federal
Characterization of mouse ocular responses (Microscopy) to a 35-day (RR-9) spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
National Aeronautics and Space Administration —
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was... -
Federal
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Estrous Cycle Monitoring)
National Aeronautics and Space Administration —
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle... -
Federal
Effect of varying amounts of simulated lunar soil batch #005 upon growth of lettuce explants
National Aeronautics and Space Administration —
The following general conclusions can be made concerning the use of tissue culture for assaying the effects of mineral elements from simulated lunar soil or other... -
Federal
Simulated Galactic Cosmic Ray Exposure Activates Dose-Dependent DNA Repair Response and Downregulates Glucosinolate Pathway in Arabidopsis Seedlings
National Aeronautics and Space Administration —
This study's objective was to develop an understanding of the biological effects of space radiation on plants with the goal of producing fresh food during long... -
Federal
A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space
National Aeronautics and Space Administration —
Bacterial behavior has been observed to change during spaceflight. Higher final cell counts, enhanced biofilm formation, increased virulence, and reduced... -
Federal
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Brain, Western Blot and ECLIA)
National Aeronautics and Space Administration —
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to... -
Federal
NASA Aircraft Bioaerosol Collector (ABC) -2
National Aeronautics and Space Administration —
Several studies have reported that microorganisms are co-transported with globally dispersed aerosols and that microbial DNA and viable cells have been detected at... -
Federal
Characterization of Epigenetic Regulation in an Extraterrestrial Environment: The Arabidopsis Spaceflight Methylome
National Aeronautics and Space Administration —
When germinated and grown on-board the ISS (International Space Station), plant do not exhibit abnormal structures but they do have altered growth habits and this... -
Federal
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station.
National Aeronautics and Space Administration —
Efforts to understand the impact of spaceflight on the human body stem from growing interest in long-term space travel. Multiple organ systems are affected by...
288 datasets found