288 datasets found
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Federal
Densely Ionizing Radiation Effects on the Microenvironment Promote Aggressive Trp53 Null Mammary Carcinomas
National Aeronautics and Space Administration —
Densely ionizing radiation is a major component of the space radiation environment and has potentially greater carcinogenic effect compared to sparsely ionizing... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum longus muscle transcriptomic and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited... -
Federal
Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats from STS-62
National Aeronautics and Space Administration —
This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing... -
Federal
Spaceflight-induced (STS-62) vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation
National Aeronautics and Space Administration —
There is often a reciprocal relationship between bone marrow adipocytes and osteoblasts, suggesting that marrow adipose tissue (MAT) antagonizes osteoblast... -
Federal
Transcriptional and Post transcriptional Regulation of Seedling Development in Microgravity
National Aeronautics and Space Administration —
The project focuses on understanding the transcriptional and post-transcriptional mechanisms that regulate early seedling development in spaceflight and microgravity.... -
Federal
Persistence of Escherichia coli in the microbiomes of mizuna mustard (Brassica rapa var. japonica) - does seed sanitization matter?
National Aeronautics and Space Administration —
Seed sanitization via chemical processes removes/reduces microbes from the external surfaces of the seed and thereby could have an impact on the plants' health or... -
Federal
Altered Quorum Sensing and Physiology of Staphylococcus aureus During Spaceflight Detected by Multi-omics Data Analysis (BRIC-23: Secretomics)
National Aeronautics and Space Administration —
Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor for opportunistic infections. Because of the potential threat of S. aureus to... -
Federal
Effects of 32 Days Aboard the ISS on Quadricep Tendon Nanomechanics (Quadricep femoris tendon, RR-1 and Atomic Force Microscopy)
National Aeronautics and Space Administration —
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to... -
Federal
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures (Flow Cytometry, Blood)
National Aeronautics and Space Administration —
In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle... -
Federal
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Grip; force transducer)
National Aeronautics and Space Administration —
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle... -
Federal
Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS)
National Aeronautics and Space Administration —
Microbes are present in all occupied indoor environments, including the International Space Station (ISS). An unexpected ventilation system failure may lead to... -
Federal
Effects of Space Flight on Inflammasome Activation in the Brain of Mice (Cortex; ECLIA)
National Aeronautics and Space Administration —
Space exploration exposes astronauts to stressors that alter the immune response, rendering them vulnerable to infections and diseases. In this study, we aimed to... -
Federal
Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats
National Aeronautics and Space Administration —
The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed... -
Federal
Head-Down Tilt As a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight (Optic Nerve, MRI)
National Aeronautics and Space Administration —
This ground-based program was intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and... -
Federal
Spatial characterization of microbial communities on multi-species leafy greens grown simultaneously in the Veggie vegetable production systems on the International Space Station VEG-03E
National Aeronautics and Space Administration —
Investigates the microbial communities of plants and Veggie pillow components with culturable and non-culturable methods providing qualitative and quantitative data.... -
Federal
Drosophila parasitoids go to space: Unexpected and differential effects of spaceflight on hosts and their parasitoids - Wasp Leptopilina heterotoma 14 data
National Aeronautics and Space Administration —
In this study, fruit flies and their parasitic wasps were sent to the ISS to examine changes in host immunity and parasite virulence. Key findings from this work are... -
Federal
Transcriptional profiling of tibialis anterior muscle from mice flown on the RR-23 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-23 mission (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of... -
Federal
Resequencing of select microbial isolates from the International Space Station with the Nanopore MinION
National Aeronautics and Space Administration —
Microbial isolates from the NASA Space Biology-funded microbial tracking experiments were re-sequenced using the Oxford Nanopore MinION. -
Federal
Transcription profiling of rat response to changes in developmental stage - 3 types of tissue, 3 gravity conditions, 2 developmental conditions
National Aeronautics and Space Administration —
Transcriptional crosstalk between mammary gland, liver and adipose tissue Experiment Overall Design: Pregnant and Lactating rats exposed to 3 gravity conditions -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse kidney transcriptomic, proteomic, and epigenomic data
National Aeronautics and Space Administration —
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited...
288 datasets found