97 datasets found
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Federal
The dominance of the population by a selected few: power-law behaviour applies to a wide variety of genomic properties
U.S. Department of Health & Human Services —
The sequencing of genomes provides us with an inventory of the 'molecular parts' in nature, such as protein families and folds, and their functions in living... -
Federal
Obtaining reliable information from minute amounts of RNA using cDNA microarrays
U.S. Department of Health & Human Services —
Background High density cDNA microarray technology provides a powerful tool to survey the activity of thousands of genes in normal and diseased cells, which helps us... -
Federal
Genomic approaches to research in pulmonary hypertension
U.S. Department of Health & Human Services —
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic... -
Federal
The cloning, genomic organization and tissue expression profile of the human DLG5 gene
U.S. Department of Health & Human Services —
Background Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is... -
Federal
Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients
U.S. Department of Health & Human Services —
Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to... -
Federal
Vector algebra in the analysis of genome-wide expression data
U.S. Department of Health & Human Services —
Background Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these... -
Federal
A modification of Representational Difference Analysis, with application to the cloning of a candidate in the Reelin signalling pathway
U.S. Department of Health & Human Services —
Background cDNA-RDA is one of the subtractive cloning techniques used to isolate differentially expressed genes between two complex cDNA populations. In the present... -
Federal
Rhythmic expression of
U.S. Department of Health & Human Services —
Background Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the... -
Federal
Characterization of the mouse
U.S. Department of Health & Human Services —
Background DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor,... -
Federal
Expression profiles during honeybee caste determination
U.S. Department of Health & Human Services —
Background Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms, this developmental switch depends... -
Federal
Genomic organization and alternative splicing of the human and mouse RPTPρ genes
U.S. Department of Health & Human Services —
Background Receptor protein tyrosine phosphatase rho (RPTPρ, gene symbol PTPRT) is a member of the type IIB RPTP family. These transmembrane molecules have been... -
Federal
A transcriptional response to Wnt protein in human embryonic carcinoma cells
U.S. Department of Health & Human Services —
Background Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known... -
Federal
Computational prediction of membrane-tethered transcription factors
U.S. Department of Health & Human Services —
Background Sequestration of transcription factors in the membrane is emerging as an important mechanism for the regulation of gene expression. A handful of membrane-... -
Federal
Improved analytical methods for microarray-based genome-composition analysis
U.S. Department of Health & Human Services —
Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that... -
Federal
Analysis of stress- and host cell-induced expression of the
U.S. Department of Health & Human Services —
Background The gene encoding the inorganic pyrophosphatase (PPase) of the intracellular pathogen Legionella pneumophila is induced during intracellular infection, but... -
Federal
Little qualitative RNA misexpression in sterile male F
U.S. Department of Health & Human Services —
Background Although the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles... -
Federal
Sources of nonlinearity in cDNA microarray expression measurements
U.S. Department of Health & Human Services —
Background A key assumption in the analysis of microarray data is that the quantified signal intensities are linearly related to the expression levels of the... -
Federal
Analysis of strain and regional variation in gene expression in mouse brain
U.S. Department of Health & Human Services —
Background We performed a statistical analysis of a previously published set of gene expression microarray data from six different brain regions in two mouse strains.... -
Federal
Efficacy of SSH PCR in isolating differentially expressed genes
U.S. Department of Health & Human Services —
Background Suppression Subtractive Hybridization PCR (SSH PCR) is a sophisticated cDNA subtraction method to enrich and isolate differentially expressed genes.... -
Federal
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application
U.S. Department of Health & Human Services —
Background A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic...
97 datasets found