8 datasets found
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Federal
Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats
U.S. Department of Health & Human Services —
Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural... -
Federal
Connexin-mimetic peptide Gap 27 decreases osteoclastic activity
U.S. Department of Health & Human Services —
Background Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts... -
Federal
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
U.S. Department of Health & Human Services —
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo... -
Federal
Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse
U.S. Department of Health & Human Services —
Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact... -
Federal
Bone loss: Factors that regulate osteoclast differentiation - an update
U.S. Department of Health & Human Services —
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among... -
Federal
Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines
U.S. Department of Health & Human Services —
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and... -
Federal
The molecular mechanism of osteoclastogenesis in rheumatoid arthritis
U.S. Department of Health & Human Services —
Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage lineage under the control of bone-forming osteoblasts. We have cloned an... -
Federal
The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
U.S. Department of Health & Human Services —
The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the...
8 datasets found